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Phosphatidylinositol-3,4,5-triphosphate activates downstream AKT and then regulates the proliferation, survival and energy metabolism of osteoblasts through mammalian target of rapamycin, BCL-2-antagonist of cell death, forkhead box O1, and other pathways [28, 29]

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Evaluation of the osteogenic potential of rat adipose-derived stem cells with different polycaprolactone/alginate-based nanofibrous scaffolds: an in vitro study