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Several rodent studies link BPC-157 to the VEGF-receptor-2 / Akt / endothelial nitric oxide synthase (eNOS) signaling axis, which would connect its reported angiogenic and vasodilatory effects to a single upstream pathway

In LDH, the inhibition of the DNA methyltransferase DNMT3B effectively prevents the onset of ferroptosis in NPCs and enhances cellular activity and mitochondrial function, suggesting a critical role in the regulation of iron homeostasis (183)

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It has been speculated that members of the thiosulfate sulfur transferase (TST) family (which can use thiosulfate and/or GSSH to generate an enzyme-bound hydropersulfide) transfer persulfides to other proteins (Mishanina et al., 2015)

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