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B7-33 attenuates myocardial infarction-related adverse cardiac remodeling in mice

Here, we report the discovery of a series of fragment hits that bind at the interface between the TRFH domain of TRF1 (TRF1 TRFH ) and a peptide of TIN2 (TIN2 TBM ), an interaction essential for the recruitment of TRF1 to shelterin, using X-ray crystallography (XChem) and ligand-observed NMR (LO-NMR) fragment screening

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It requires a complete review of clinical data, toxicology data, manufacturing processes, finished product formulations, therapeutic indications, and administration routes