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There is also some limited evidence suggesting that individuals who carry certain polymorphisms in genes involved in vitamin C transport and detoxification mechanisms may have lower plasma vitamin C concentrations even with high vitamin C intakes (see also Vascular complications of diabetes mellitus) (reviewed in 27)

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FDAs Red Flag List: Substances of Concern The FDA maintains and updates a list of Category 2 bulk drug substances that may present significant safety risks

No participants in any clinical trial developed detectable anti-AOD9604 antibodies, even after 24 weeks of continuous exposure