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Tomato jasmonic acid-deficient mutant spr2 seedling response to cadmium stress

We found that ROS production occurs efficiently in peptides with two coordinating histidine side chains

10.1016/j.redox.2025.103661 39 De MagistrisL.PicardiA.SiniscalcoD.RiccioM

It may also provide a logical explanation for why UA can function as an antioxidant to block the effects of exogenous peroxynitrite to uncouple endothelial NO synthase[18] yet in the presence of high concentrations of UA favor the reduction of intracellular NO levels.[16] It also provides an explanation for why UA infusions into healthy individuals (likely with good intracellular glutathione stores) do not cause endothelial dysfunction acutely.[25] Finally, it could explain the recent report[26] that allopurinol improves endothelial function by blocking oxidative stress rather than by lowering serum UA concentrations