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Therefore, a 1-week washout period was deemed sufficient to prevent carryover effects, consistent with protocols used in similar crossover designs involving acute L-carnitine supplementation

The chronic immune activation and mycotoxin burden of systemic Candida overgrowth places sustained demand on the hypothalamic-pituitary-adrenal (HPA) axis, progressively depleting cortisol reserve and producing the flat diurnal cortisol curve characteristic of adrenal fatigue

Sizing and shaping the nucleus: mechanisms and significance

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