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Whether peripheral cytokines penetrate the brain to induce a damaging microglial neuroinflammatory state and grey matter loss [15] or exert direct effects on synaptic development, function and survival is debated [16,17,18]

Pituitary adenylate cyclase activating polypeptide, growth hormone (GH)-releasing peptide and GH-releasing hormone stimulate GH release through distinct pituitary receptors

Acknowledgments I am greatly indebted to Paola Bressan for major edits of an early version of this article, for insightful comments on a late version, for making me aware of various relevant articles, and for technical assistance

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