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However, l-dopa possesses many pharmacokinetic and pharmacodynamic drawbacks leading to pulsatility (short half-life), reduced availability (limited and variable reabsorption, and the requirement for declining aromatic l-amino acid decarboxylase), and off-target metabolism and sites (endothelium, glial cells, serotonin neurons and so on)

The Sikiric group has published extensively on gastric ulcer, TNBS-induced colitis, and hepatic ischemia-reperfusion models (Sikiric et al

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Acta Pharmacol Sin