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As your body works harder to regulate temperature, it can experience electrolyte imbalances , low-grade inflammation , oxidative stress , and cellular DNA damage

Nutr (Burbank, Los Angeles Cty, Calif)

In humans, calbindin-D 28K is encoded by the CALB1 gene which is expressed in the kidney tubule and is responsible for participating in renal Ca 2+ reabsorption

Brinton RD, Swanson HM, Irwin RW

Dopamine agonists, partial agonists and dopamine reuptake inhibitors (alone or in combination with serotonergic and noradrenergic agents) have shown some efficacy in treating mood symptoms and cognitive deficits and co-morbid symptoms of apathy and anxiety [46, 144]