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In a randomized controlled clinical trial, leg ulcers treated with EpiFix in addition to multilayer compression therapy had an average reduction in size over four weeks of 48.1% compared with 19% for those treated with compression only (Serena 2014)

Someones preferences, lifestyle, and ability to take it consistently play a major role, too

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Thats huge because melatonin affects everything from sleep to growth hormone secretion

Neurological disturbances: Vitamins B1, B6, and B12 are involved in nerve function and can be beneficial in managing neurological disturbances such as neuropathy, nerve pain, and other nerve-related symptoms