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With regards to human health, eating crops grown in soil contaminated by Cd can lead to cancer, bone lesions, lung dysfunction, renal dysfunction, anemia and other diseases [8,9,10]

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GSH binding to NAPQI also increased the number of necrosed cells, with the variation in the number of zonal necrosed cells increasing from 0.7 times at 20% zonation to 3.5 times at 80% zonation

However, further dose-response analysis and adjustment for intake of other vitamin and mineral supplements indicated that all-cause mortality risk was significantly increased by 7% only at a dose of 2,000 IU/day, which is notably higher than the UL for adults (1,100 IU/day of synthetic tocopherol or 1,500 IU/day of natural tocopherol)

Biosci Biotechnol Biochem 61:13791381