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Despite an incomplete understanding of autoimmune disease pathogenesis, these conditions exhibit several common characteristics: (1) often unclear etiology, with some cases being spontaneous or idiopathic, while others may be linked to bacterial or viral infections or certain medications
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Another compound that was identified as potent BACH1-inhibitor was the phytocannabinoid cannabidiol (CBD), which induces nuclear export and degradation of the transcription factor ( In vitro models have confirmed CBDs antioxidant and anti-inflammatory properties, acting through HMOX-1 and inducing the downregulation of pro-inflammatory cytokines (Juknat et al., 2016
Addressing these issues will require extensive animal studies and clinical trials to ensure both efficacy and safety
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