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After a follow-up visit 6 months later (from initial presentation), Helen's RF and CRP levels remained above normal, and she continued to have severe joint pain and radiographic evidence of progressive joint damage despite the increase in her dosage of methotrexate 3 months earlier

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Bioinformatics analyses GeneSet enrichment analysis (GSEA) (1) was performed with the C2_cp_KEGG gene set using GSEA version 4.0 software