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The assay includes a control test tube to ensure the accuracy of the GPx activity measurements and address potential interferences from other thiols and sample components

Despite its prevalent use in chemotherapy, 5-FU monotherapies are reported to have significant toxic effects on heart [3]

SARS-CoV-2 mainly destroys pulmonary surfactant-secreting type II alveolar cells (Wang et al., 2021a), that normally decrease the air/tissue surface tension and block TLR4 in the lungs, promoting ARDS and inflammation

Because it depends on the regulation of certain nuclear receptors, induction of CYP3A and P-gp occurs with a delay (95, 96)

Consequently, these compounds have not undergone systematic and standardized experimental pharmacokinetic research on new drugs