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Advanced glycation end-products (AGEs) create abnormal cross-links that stiffen collagen fibers, reducing their ability to support smooth skin and increasing brittleness that leads to deeper wrinkle formation

Common side effects include: Dry lips and dry skin (very dry, like constantly reaching for Aquaphor dry) Sun sensitivity SPF isnt optional An initial breakout in the first few weeks (even months in some cases) Mood shifts (always share your mental health history with your provider) More rarely, it can affect your liver, cholesterol, or digestion which is why monthly labs are standard

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Common Symptoms and Signs Symptoms of MTHFR mutations can range widely, but often include fatigue, mood disorders, and other symptoms related to folate metabolism