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4.2.5 Oxidative stress and inflammatory response An increased abundance of Gram-negative bacteria in the gut of PCOS patients elevates circulating LPS, which activates the LPS/TLR4 pathway and sustains systemic chronic low-grade inflammation (73)

Arch Biochem Biophys 420:209216 Walker M, Vergely C, Lecour S, Abadie C, Maupoil V, Rochette L (1998) Vitamin E analogues reduce the incidence of ventricular fibrillation and scavenge free radicals

This caution is due to the potential of PT-141 to cause temporary rises in blood pressure

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Reduced plasma antioxidant concentrations and increased oxidative DNA damage in inflammatory bowel disease