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and because it tells cells everywhere to grow, prolonged misuse is linked to fluid retention, joint pain, enlargement of organs (acromegaly-type effects), and a theoretical increase in cancer risk (Liv Hospital)

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Therefore, it seems plausible to expect that a combination with some or all of them produces synergism and/or redundancy in their mechanisms of action, potentiating the beneficial effect over noise over-exposure

Refrigerated or frozen storage is preferred for long-term peptide stability

One significant disadvantage that might prohibit CH from being utilized in medicinal formulations is its limited dissolution at neutral pH (Almajidi et al., 2024