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The class profile of agents that elevate IGF-1 signaling applies, including the theoretical concern about IGF-1 as a mitogenic and pro-survival signal in malignant cell populations a consideration documented in the FDA-approved labels of recombinant human IGF-1 products (mecasermin), which carry contraindications and warnings related to neoplasia

Both can be safely combined to provide comprehensive support

The exact cell populations and cellular cascades responsible for ROS production in the female reproductive system remain unknown, but several studies have found that ROS, antioxidants, and their genes are present in various reproductive milieus, including follicular and tubal fluids, oocytes, and embryos [18,19]

10.1002/advs.202400665 Adv Sci

doi: 10.1002/brb3.1852