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Medical Conditions & Medications: Patients with certain conditions, such as gastroesophageal reflux disease (GERD), or those taking specific medications like Vitamin D3 supplements, may have an elevated risk of experiencing eye color changes

Tucson Wellness MD, a licensed integrative clinic, cites 250-500 mcg once or twice daily for joint and gut protocols, typically over a 4-6 week cycle, with other indications ranging up to 750 mcg daily

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However, the report describes the woman's symptoms as "idiosyncratic" and concedes they may have been caused by another ingredient in her supplement.33 Even if you feel that your risk of adverse events is low, we recommend speaking with your doctor before incorporating milk thistle (or any supplement) into your regimen