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Some individuals develop: Orthostatic intolerance Heart rate variability changes Postural Orthostatic Tachycardia Syndrome (POTS)-like symptoms Temperature dysregulation (19) These patterns reflect neuroimmune interaction rather than isolated cardiac pathology

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The fact that ordered parts of a protein molecule are insensitive to proteolysis gives raise to the sequence/structure paradigm of limited proteolysis, where higher order structure and not primary sequence is the main determinant of the site of initial hydrolysis (Hubbard, 1998)