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Common culprits include inadequate protein intake, insufficient sleep, excessive stress, and medication interactions

Moreover, it is plausible that the reduction in total peripheral resistance seen after GH administration in adult growth hormone deficiency is mediated by nitric oxide (124)

It has long been known, for example, that whereas many MOPr agonists such as [D-Ala 2 , N -MePhe 4 ,Gly-ol 5 ]enkephalin (DAMGO) and etorphine are able to induce arrestin interaction with the MOPr and lead to extensive MOPr internalization, other agonists such as morphine are not (Keith et al ., 1996

J Mol Cell Cardiol 28:667678