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human evidence is limited and the combination is unstudied, so individual results vary

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Coders and CDI specialists must recognize all of them and map appropriately to ICD-10-CM codes

In the ALS rodent model, the mitochondrial biogenesis regulator PGC-1 has been demonstrated to protect upper motor neurons, participate in the production of neuromuscular junctions in lower motor neurons, and regulate oxidative stress in sensory neurons (Kuczynska et al., 2021)