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These findings are documented but derive predominantly from animal studies and should be interpreted accordingly

However, it is not known whether vitamin B 12 supplementation, in addition to folic acid supplementation, may be beneficial in the prevention of NTD (62) randomized controlled trials are needed to address this question

Therefore, methionine has to be exogenously introduced into the human body either within the diet or as a supplement.12 Methionine serves several key roles in the human body such as: Substrate in the production of critical hormones and proteins including L-cysteine, carnitine, adrenaline, choline, and melatonin, among others

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It does not replace vitamin B12 where deficiency is present