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During the catabolism of polyamines (such as spermidine and spermine), significant amounts of hydrogen peroxide (H 2 O 2 ) are produced as byproducts

"The origin of modern metabolic networks inferred from phylogenomic analysis of protein architecture"

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Increased ACSL4 expression is observed in tumors, particularly triple-negative breast cancer, where higher ACSL4 levels may enhance sensitivity to radiotherapy and chemotherapy [31]