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JZ and LL: Article guidance, Paper revision and Paper submission

It neutralises free radicals and prevents them from causing cellular damage

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It also induces the release of mitochondrial DNA from cells [68]

Pembrolizumab and nivolumab which have also been in a category of immune checkpoint inhibitors are approved by FDA as a first line therapy in patients having cisplatin insensitive recurrent or metastatic HNSCC [19,20,21]