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Quantitative analysis of fluorescence intensity was performed using ImageJ software

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The First-Pass Problem: What Happens in the Liver First-pass metabolism refers to the phenomenon where orally administered compounds are absorbed through the intestinal wall, enter the hepatic portal vein, and are metabolised by liver enzymes before reaching systemic circulation

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Furthermore, the co-localization of UCN1 and CART has been also shown in the human EWcp (Fig