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By contrast with the intra(per)-oral application of the strong alcohol, the innate effect of L-NAME and additional NOS-blockade existed with the intra(per)-oral application of the strong alcohol (tongue lesions aggravated), and further, with additional subsequent immediate intragastric application of the strong alcohol (tongue and esophagus lesions were aggravated), thus, a non-definitive NO-system failure was quickly initiated

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