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Thymosin beta-4 (the molecule behind TB-500) is best supported for central neurorestoration and remyelination : driving oligodendrocyte-progenitor differentiation and remyelination, stimulating neurogenesis and angiogenesis in injured cortex and hippocampus, and promoting neurite outgrowth in models where lesion size does not change but function still improves

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In some embodiments, the otic formulation or composition comprises about 0.9% by weight of the silicon dioxide