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GSH replenishment in human tissues is difficult due to its shorter half-life, and not easy to penetrate the plasma membrane hence use of prodrugs/precursors such as cysteine, and glycine is the most promising approach 4,45

Caregivers should avoid self-prescribing high doses of vitamins or minerals, as excessive intake can lead to toxicity or nutrient imbalances

Increased lactate concentrations are also intriguing in the context of one of the influential hypotheses on the provenience of ME/CFS symptoms, a state of chronic, low-level neuroinflammation [61]

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