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Dahabreh IJ, Giannouli S, Gota V, Voulgarelis M

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Relatedly, there is evidence that antioxidants might need to be tailored to counter the specific source of reactive oxygen species for maximal therapeutic benefit [65]

A 2006 Achilles-detachment study by Krivic and colleagues in the same journal applied BPC-157 intraperitoneally once daily at 10 g/kg, 10 ng/kg, or 10 pg/kg for 30 days in rats and reported that tendon-to-bone tissue, which did not heal spontaneously in saline controls, recovered with BPC-157 treatment, with directionally improved load-to-failure, stiffness, Young's modulus, and collagen organization at days 121, including in animals where healing had been impaired by 1 mg/kg 6-methylprednisolone though the abstract does not report numeric effect sizes or p-values

Since L-arginine in mammals is derived mostly from renal de novo synthesis and dietary intake, CAT1 at the BBB would function as a supply pathway for L-arginine to the brain