PVA-based hydrogels cross-linked with a ROS-responsive linker have also been obtained by modifying the composition of the hydrogels, which gradually degrade due to ROS-responsive cleavage to release loaded mupirocin and the growth factor GM-CSF, which can inhibit bacterial growth (Zhao et al., 2020)
Methods A PRISMA-guided systematic review (Figure 1) was performed using PubMed and MEDLINE databases, employing search terms glutathione AND topical AND skin OR dermatology, yielding 446 articles with no time restriction
Medical and Editorial Standards Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims
Regarding the mechanism of PBMs action on chondrocytes, studies confirm that PBM upregulates the gene and protein expression of type II collagen and aggregated proteoglycans, significantly promoting chondrocyte proliferation and activity ( in vitro experiments reveal that PBM, through close-range efficient irradiation, simultaneously activates the Sox9-centred ECM synthesis pathway while suppressing the inflammation-catabolism pathway mediated by NF-B and others