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Approaches such as intrathecal, intracerebroventricular, and intraparenchymal injections, as well as transient BBB disruption, have been employed to deliver drugs with limited CNS bioavailability (Rezaee et al., 2025)

Regeneration of antioxidant activity of vitamin E: Vitamin C (ascorbate) regenerates the antioxidant activity of -tocopherol and is oxidized to dehydroascorbate in the process

S0894-1130(20)30012-0.doi:10.1016/j.jht.2019.12.013

DOI: 10.1038/s41380-021-01077-2

Animal models and observational human data on individual components suggest improvements in lean-to-fat ratio, with retained nitrogen balance during caloric restriction