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Tryptophan metabolic dysregulation plays a pivotal role in DM pathogenesis through three primary pathways, including the indole, kynurenine, and serotonin pathways (Gao et al., 2023)

Furthermore, rATRAM-GRA8-M/AS demonstrated significant therapeutic effects in a mouse model with HCT116 xenografts, with noticeable inhibition in tumor growth in mice [94]

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