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Mechanistically, luteolin activates antioxidant defense pathways, particularly Nrf2-regulated enzymes, while modulating PI3K/AKT signaling involved in granulosa cell survival and metabolic support of the oocyte (Pan et al., 2025)

310 The full scope of proteins affected by this pathway, estimated at approximately 300 in the mammalian genome, remains to be explored

Systematic review with meta-analysis: the efficacy of probiotics in inflammatory bowel disease

These regulatory effects are demonstrated to co-regulate the downstream glutamine metabolism targets and to show their effects on cancer cell invasion and metastasis

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