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In addition, green tea polyphenols can activate AMP-activated protein kinase in the liver, skeletal muscle, and adipose tissues and thereby can induce substrate oxidation (Reference Yang, Zhang and Zhang51)

Using the GHGGHG peptide as baseline, we exchanged the first histidine residue (GXGGHG) with plausible copper coordinating side chains and a few non-plausible residues as control (Fig

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