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Systemic Implications If an 85 mg/day human protocol were sustained over 8 weeks to match the murine intranasal timeline, it would cross into a biochemically hazardous profile: Hepatic Accumulation: The primary adverse effect of chronic copper toxicity is hepatotoxicity

Then, over roughly six months, the well-funded platforms will out-compete the fly-by-night operators on price and credibility, and the smaller players will either get bought or die

doi: 10.1111/liv.15546 26 SuJGuoLWuC

Free Radic Biol Med 95:2742

Disrupted intestinal permeability is closely associated with dysbiosis, and there is reason to think that repairing the mucosal barrier creates a more hospitable environment for a healthy microbial community