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For instance, GF mice have modified gut shape, characterized by diminished total intestinal mass, expanded cecum, shorter and thinner villi, and depleted mucus layers, decreased epithelial cell renewal, and impaired intestinal motility 12

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Interestingly, unlike in preadipocytes, GPR146 knockdown in mature adipocytes did not alter the expression of PPARG and CEBPA , the key transcriptional regulators of adipogenesis (Supplementary Fig

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