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Moreover, a blocking study demonstrated SSTR-specific uptake after HDACi treatment, indicating SSTR-upregulation

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These lead to oxidative and nitrosative stress, respectively, a condition where cellular structure and function are more damaged, thereby disrupting intracellular homeostasis

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Hoff G, Bernklev T, Johnsen L, Reitsma L, Sina D, Lauzike A, Gibbs C, Carlsen E, Lende TH, Narvestad JK, Kildahl R, Omdal R, Kvaly JT, Siland H