1 Introduction Bone defects are commonly encountered in clinical practice and can arise from various causes, including trauma (e.g., fractures), age-related bone loss (e.g., osteoporosis), infections (e.g., osteomyelitis and periodontitis), cancer (e.g., surgical resection), genetic diseases (e.g., inherited bone marrow failure syndrome), and congenital defects (e.g., cleft palate)
Dehydration Lack of hydration can cause the skin to appear dull and sunken, making dark circles more prominent
Blum, R
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Slivka A, Mytilineou C, Cohen G