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Low-BMI, sub-160 lb, older, or side-effect-sensitive non-micro users often start at 0.3 mg, with the band still building to at least 1 mg before response is judged

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One study suggested that the success rate of endoscopic hemostasis for patients with an INR between 1.3 and 2.7 is comparable to that of patients who are not receiving anticoagulants, and the study was not powered to determine the success rate for an INR of more than 2.7 (Am J Gastroenterol

A compound affecting so many biological pathways could easily have subtler harms that small trials (or enthusiastic investigators) might miss