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(1) ROS directly attacks the mitochondria of chondrocytes, causing leakage of the electron transport chain (ETC) and further generating superoxide anion (O ), which forms a vicious cycle, inducing collapse of mitochondrial membrane potential and ATP synthesis disorder

syndrome, m., Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases

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PMID: 14676844

This brings us to the next speculation: could the presence of Jmjd3 or the ability to recruit it to the pro-neurogenic TFs be a molecular determinant of neurogenic activity in the adult brain