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The authenticity of the HCC-1806, MDAMB231, MDAMB468, JIMT-1 and A549 cell lines was confirmed by STR profiling

MTHFR shows tendency A genetic variant may affect risk or nutrient handling, but it does not establish the patients current methylation state

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Future research needs to continuously deepen the mechanistic analysis of the HIF-ROS interaction network to optimize therapeutic strategies based on redox homeostasis