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doi: 10.1038/ni.3775 104 MalikBTByrneKTVellaJLZhangPShabanehTBSteinbergSMet al

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Molecular Structure Peptide Sequence: GlyHisLys Complex: GHK coordinated with Cu Molecular Formula (GHKCu): CHCuNO Molecular Weight: 340.88 g/mol Peptide Class: Copperbinding tripeptide Form: Lyophilized powder, researchgrade The copper complex adopts a squareplanar coordination geometry involving the histidine imidazole and terminal amine groups

Pharmacological targeting of CHAC1-mediated processes therefore represents a rational therapeutic strategy, potentially disrupting the cycle of GSH depletion, ER stress amplification and iron-dependent peroxidation that drives neuronal loss