A deficiency can lead to megaloblastic anaemia, a condition that causes symptoms like weakness and fatigue
The phase 3 TRIUMPH-4 data showed these rates at 9 mg and 12 mg doses respectively: Nausea: 38.1% and 43.2% (vs 10.7% placebo) Diarrhea: 34.7% and 33.1% (vs 13.4% placebo) Constipation: 21.8% and 25.0% (vs 8.7% placebo) Vomiting: 20.4% and 20.9% (vs placebo) These numbers are higher than cagrilintide monotherapy across the board
If increasing retatrutide from 2 mg to 4 mg, hold cagrilintide at its current dose
If youve had gastrointestinal surgery, your digestive system may not be able to efficiently absorb vitamin B-12, which can lead to a need for vitamin B-12 injections
Essential Extras: In July 2025, GenoGenix initiated a large recall of semaglutide, tirzepatide, retatrutide, GLP-1 vitamin combination products, and 54 additional compounded injectables, including vitamins and vitamin blends like Amino Blend, Vitamin D-3, Lipo MIC +B12 Methylcobalamin, and more, due to product sterility problems