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Tobacco contains approximately 4,000 chemicals, of which nicotine, carbon monoxide and other components stimulate blood pressure, lead to coronary AS, increase blood and platelet viscosity, reduce the ability to dissolve blood clots and oxygen-carrying capacity of hemoglobin, and even induce ventricular fibrillation, increasing the incidence of cardiovascular events (46, 47)

The albumin association produces a depot effect that substantially extends the circulating half-life compared to native amylin, whose unmodified form is cleared in minutes (CAS 2196070-45-4

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