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Numerous other studies have looked into melatonins effectiveness in promoting quality sleep, finding that melatonin supplementation can aid disrupted circadian cycles, 14 decrease daytime sleepiness, 15 improve sleep quality for secondary sleep disorders, 16 and improve sleep-wake rhythm and endogenous melatonin rhythm

Some individuals are slow responders and dont feel full effects until week 8-10

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Hossain et al

The analytical technique in that study (liquid chromatographyisotopic dilution mass spectrometry) more closely resembles the LCMS/MS assay we used than does the HPLC technique used by Borgstrm and colleagues in their 1986 study [4]