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This method can be used to demonstrate that the synergistic effect of one or more compounds provided herein in combination with known chemotherapeutic agents can reduce leukemic blood cell counts as compared to treatment with known chemotherapeutic agents (e.g., Gleevec) alone under the conditions tested

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This means AOD 9604 can be used for extended periods without diminishing returns from antibody-mediated inactivation

74, 75, 76, 77 The underlying mechanism of increased eNOS expression likely involves increased endothelial production of hydrogen peroxide, which has been shown to increase the expression of eNOS at the transcriptional and translational level

For injectable protocols, clinical oversight involving APRN intake and baseline photography is crucial for accurate assessment and adjustment