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Because DNA is an add-on to RNA biosynthesis, deoxyribonucleotides can only be synthesized via the reduction of ribonucleotides by RNR, a process which is unsustainable without the participation of one or both of the thioredoxin and glutaredoxin systems

Vascular Lesions Introduction The liver has a dual blood supply consisting of a relatively major (about 75%) venous (portal) supply via the hepatic portal vein, which carries venous blood that is largely depleted of oxygen, and relatively minor (about 25%) arterial blood supply, via the hepatic artery

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Reperfusion occurring shortly after ischemia reduces infarct volume, but at a later period may exacerbate ischemic injury [10]