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This trend is associated with substantial increases in morbidity and mortality, driven by complications including type 2 diabetes (T2D), metabolic dysfunction-associated steatotic liver disease (MASLD), and cardiovascular disease

Moreover, direct NAD + supplementation in naturally aging mice restores oocyte numbers and developmental potential, leading to significant improvement in pregnancy outcomes [361]

Evidence ranges from international approvals and randomized trials to preclinical and community-use data

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