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84,85 In a crossover study of healthy dogs taking the steroid prednisolone, SAMe supplementation at 10 mg/kg body weight twice daily for 42 days was found to reduce blood markers of liver oxidative damage, although the dogs still developed signs of steroid-induced liver disease

Individuals with Raynauds disease experience exaggerated vascular responses to cold that can cause tissue damage and should avoid cold therapy

14 Adults under 50: ~2.4 mcg per day Adults over 50: 2.4 mcg per day Older adults are advised to supplement with B12 where necessary due to the reduced stomach acid and intrinsic factor and/or medications

The gap is in large-scale human randomised controlled trials, which have not yet been conducted